Skeletal muscle dysfunction is associated with derangements in mitochondrial 1 bioenergetics ( but not UCP 3 ) in a rodent model of sepsis 2 3
نویسندگان
چکیده
Skeletal muscle dysfunction is associated with derangements in mitochondrial 1 bioenergetics (but not UCP3) in a rodent model of sepsis 2 3 Parjam Zolfaghari, Jane E Carré, Nadeene Parker, Nancy A Curtin, Michael R Duchen, 4 Mervyn Singer. 5 1 Bloomsbury Institute for Intensive Care Medicine, University College London, Cruciform 6 Building, Gower Street, London WC1E 6BT, UK 7 2 National Heart and Lung Institute, Imperial College London, London, UK 8 3 Department of Cell and Developmental Biology, University College London, Gower 9 Street, London WC1E 6BT, UK 10 11 Corresponding author: 12 Parjam S Zolfaghari 13 Current address: Adult Critical Care Unit, 4 Floor, Royal London Hospital, Barts Health NHS 14 Trust, Whitechapel, London E1 1BB 15 Email: [email protected] 16 Tel. +44 (0) 7712673051 17 18 19 Articles in PresS. Am J Physiol Endocrinol Metab (February 24, 2015). doi:10.1152/ajpendo.00562.2014
منابع مشابه
CALL FOR PAPERS Mitochondrial Dynamics and Oxidative Stress Skeletal muscle dysfunction is associated with derangements in mitochondrial bioenergetics (but not UCP3) in a rodent model of sepsis
Zolfaghari PS, Carré JE, Parker N, Curtin NA, Duchen MR, Singer M. Skeletal muscle dysfunction is associated with derangements in mitochondrial bioenergetics (but not UCP3) in a rodent model of sepsis. Am J Physiol Endocrinol Metab 308: E713–E725, 2015. First published February 24, 2015; doi:10.1152/ajpendo.00562.2014.—Muscle dysfunction is a common feature of severe sepsis and multiorgan failu...
متن کاملSkeletal muscle dysfunction is associated with derangements in mitochondrial bioenergetics (but not UCP3) in a rodent model of sepsis.
Muscle dysfunction is a common feature of severe sepsis and multiorgan failure. Recent evidence implicates bioenergetic dysfunction and oxidative damage as important underlying pathophysiological mechanisms. Increased abundance of uncoupling protein-3 (UCP3) in sepsis suggests increased mitochondrial proton leak, which may reduce mitochondrial coupling efficiency but limit reactive oxygen speci...
متن کاملMitochondrial dysfunction in a long-term rodent model of sepsis and organ failure.
Although sepsis is the major cause of mortality and morbidity in the critically ill, precise mechanism(s) causing multiorgan dysfunction remain unclear. Findings of impaired oxygen utilization in septic patients and animals implicate nitric oxide-mediated inhibition of the mitochondrial respiratory chain. We recently reported a relationship between skeletal muscle mitochondrial dysfunction, cli...
متن کاملUCP-mediated energy depletion in skeletal muscle increases glucose transport despite lipid accumulation and mitochondrial dysfunction.
To address the potential role of lipotoxicity and mitochondrial function in insulin resistance, we studied mice with high-level expression of uncoupling protein-1 in skeletal muscle (UCP-H mice). Body weight, body length, and bone mineral density were decreased in UCP-H mice compared with wild-type littermates. Forelimb grip strength and muscle mass were strikingly decreased, whereas muscle tri...
متن کاملChanges in uncoupling protein-2 and -3 expression in aging rat skeletal muscle, liver, and heart.
Uncoupling protein (UCP)-2 and -3 mediate mitochondrial (mt) proton leak in vitro and are potential regulators of energy expenditure and ATP production. Aging is associated with alteration of tissue functions, suggesting impaired mtATP production. To determine whether age-related changes in UCP expression occur, we measured the transcript levels of UCP-2 and -3 in skeletal muscle, liver, and he...
متن کامل